這個就是王道

身為一個熱愛美食、喜歡在城市裡挖掘驚喜的人，臺中公益路一直是我最常出沒的地方之一。這條路可說是「臺中人的美食戰場」，從精緻西餐到創意火鍋，從日式丼飯到義式早午餐，每走幾步，就會有完全不同的特色料理餐廳。

這次我特別花了一整個月，實際造訪了公益路上十間口碑不錯的餐廳。有的是網友熱推的打卡名店，也有隱藏在巷弄裡的小驚喜。我以環境氛圍、口味表現、價格CP值與再訪意願為基準，整理出這篇實測評比。希望能幫正在猶豫去哪裡吃飯的你，找到那一間「吃完會想再來」的餐廳。

評比標準與整理方向

這次我走訪的10家餐廳橫跨不同料理類型，從高質感牛排館到巷弄系早午餐，每一間都有自己獨特的風格。為了讓整體比較更客觀，我依照以下四大面向進行評比，並搭配實際用餐體驗來打分。

整體而言，我希望這份評比不只是「哪家好吃」，而是幫你在不同情境下（約會、家庭聚餐、朋友小聚、商業午餐）都能快速找到合適的選擇。畢竟，美食不只是味覺的滿足，更是一段段與朋友共享的生活記憶。

10間臺中公益路餐廳評比懶人包

公益路向來是臺中人聚餐的首選地段，從火鍋、燒肉到中式料理與早午餐，每走幾步就有驚喜。以下是我實際造訪過的10間代表性餐廳清單，橫跨平價、創意、高級各路風格。

一頭牛日式燒肉｜炭香濃郁的和牛饗宴，約會聚餐首選

走在公益路上，很難不被 一頭牛日式燒肉 的木質外觀吸引。低調卻不失質感的門面，搭配昏黃燈光與暖色調的內裝，讓人一進門就感受到濃濃的日式職人氛圍。店內空間不大，但桌距規劃得宜，每桌皆設有獨立排煙設備，烤肉時完全不怕滿身油煙味。

餐點特色

一頭牛的靈魂，絕對是他們招牌的「三國和牛拼盤」。
嚴選的和牛部位，共八個部位、十樣餐點，讓人能從牛頭一路品嘗到牛尾。
油花分布均勻、切片厚薄恰好，經過炭火烤炙後香氣四溢，焦香與油脂在口中交融，入口即化的滑順感令人難忘。
值得一提的是，一頭牛的菜單設計十分彈性
想要一次體驗完整套餐也可以，偏好客製口味則能自由單點組合，不受套餐限制，想吃什麼就點什麼。
而且每桌都能選擇「自行燒烤」或「專人代烤」服務，烤肉管家的火侯掌握與節奏讓整體體驗更輕鬆愉快。
除了主角和牛，旬味野炊飯 與 主廚冰淇淋 也是隱藏版亮點，前者粒粒分明、香氣撲鼻；後者以香草與焙茶為基底，隨季節更換口味，完美收尾。整體服務親切熱情，特別是壽星還能享有 生日畫盤驚喜，讓慶祝時刻更添儀式感。

用餐體驗

整體節奏掌握得非常好。店員會在你剛想烤下一片肉時貼心遞上夾子、幫忙換烤網，讓人完全不用分心。整場用餐過程就像一場表演，從視覺、嗅覺到味覺都被滿足。
如果是第一次約會或慶祝特別節日，這裡的氛圍既不尷尬又不吵鬧，是營造氣氛的理想選擇。

綜合評分

地址：408臺中市南屯區公益路二段162號

電話：04-23206800

官網：https://lihi2.me/Amijw

小結語

一頭牛日式燒肉不僅是「吃肉的地方」，更像是一場五感盛宴。從進門那一刻到最後一道甜點，都能感受到他們對細節的用心。
若要在公益路找一間能讓人「邊吃邊微笑」的燒肉店，一頭牛 絕對值得列入你的必訪清單。

TANG Zhan 湯棧｜文青系火鍋代表，麻香湯底與視覺美感並重

在公益路這條美食戰線上，TANG Zhan 湯棧 是讓人一眼就會想走進去的那一種。
黑灰調的現代外觀、搭配微霧玻璃與招牌的「湯棧」燈字，呈現出一種低調的時尚感。
店內設計延續品牌主題，以「湯」為靈魂打造整體體驗，從裝潢到香氣，都有濃厚的溫潤氣息。

餐點特色

湯棧最有名的當然是它的「麻香鍋」。
湯底以雞骨與多種辛香料慢熬，香氣濃郁卻不嗆辣，入口後會在喉間留下柔和的花椒香。
「招牌麻油雞鍋」與「黃金牛奶鍋」也是人氣選項，特別是在冬天，溫潤的湯底配上滑嫩肉片，讓人每一口都覺得暖心。
他們的「滷肉飯」和「香蔥豆腐皮」更是許多老客人必點的靈魂配角，簡單卻有記憶點。

用餐體驗

整體氛圍比一般火鍋店更有質感。
桌距寬敞、燈光柔和，店員動作俐落又親切。即使客滿，也不會感覺吵雜或壓迫。
不論是一個人想靜靜吃鍋、或是朋友聚餐，湯棧都能給你剛剛好的距離與溫度。
值得一提的是，上菜速度快、湯底續湯毫不手軟，細節服務到位。

綜合評分

地址：408臺中市南屯區公益路二段248號

電話：04-22580617

官網：https://www.facebook.com/TangZhan.tw/

小結語

TANG Zhan 湯棧 把傳統火鍋做出新的樣貌

 保留臺式鍋物的溫度，又結合現代風格與細節服務，讓吃鍋這件事變得更有品味。

 如果你想找一間兼具「好吃、好拍、好放鬆」的火鍋店，湯棧會是公益路上最有風格的選擇之一。

NINI 尼尼臺中店｜明亮寬敞的義式早午餐天堂

如果說前兩間是肉食愛好者的天堂，那 NINI 尼尼臺中店 絕對是想放鬆、聊聊天的好地方。餐廳外觀以白色系與大片玻璃窗為主，陽光灑進室內，讓人一踏入就有種度假般的輕盈感。假日早午餐時段特別熱鬧，建議提早訂位。

餐點特色

NINI 的菜單融合義式與臺灣人口味，選擇多樣且份量十足。主打的 松露燉飯 濃郁卻不膩口，米芯保留微Q口感；而 香蒜海鮮義大利麵 則以新鮮白蝦、花枝與淡菜搭配微辣蒜香，口感層次豐富。
此外，他們的薄餅披薩相當受歡迎，餅皮薄脆、餡料新鮮，是三五好友共享的好選擇。

用餐體驗

店內氣氛輕鬆不拘謹，無論是一個人帶電腦工作、或朋友聚餐，都能找到舒服角落。餐點上桌速度穩定，服務人員態度親切、補水與收盤都非常主動。整體節奏讓人覺得「時間變慢了」，很適合想遠離忙碌日常的人。

綜合評分

地址：40861臺中市南屯區公益路二段18號

電話：04-23288498

官網：https://nini.com.tw/

小結語

NINI 尼尼臺中店是一間能讓人放下手機、慢慢吃飯的餐廳。餐點不追求浮誇，而是以「剛剛好」的份量與風味，陪伴每個平凡午後。

 如果你在找一間能邊吃邊聊天、拍照也漂亮的早午餐店，NINI 會是你在公益路上最不費力的幸福選擇。

加分100%浜中特選昆布鍋物｜平價卻用心的湯頭系火鍋，家庭聚餐好選擇

在公益路這條高質感餐廳林立的戰場上，加分100%浜中特選昆布鍋物 走的是截然不同的路線。它沒有浮誇的裝潢、也沒有高價位的套餐，但靠著實在的湯頭與親切的服務，默默吸引許多回頭客。每到用餐時間，總能看到家庭或情侶三兩成群地圍著鍋邊聊天。

餐點特色

主打 北海道浜中昆布湯底，湯頭清澈卻不單薄，越煮越能喝出海藻與柴魚的自然香氣。
我這次點的是「牛奶昆布鍋」，入口時奶香與昆布香完美融合，搭配新鮮的牛五花肉片，滑順又不膩。
菜盤走健康取向，蔬菜比例高，連玉米、南瓜、豆皮都能吃出甜味；附餐的烏龍麵Q彈有嚼勁，吃完十分有飽足感。

用餐體驗

整體氛圍偏家庭取向，桌距寬敞、座位舒適，帶小孩來也不覺擁擠。店員態度親切，補湯、收盤都很勤快，給人一種「被照顧著」的安心感。
最難得的是，即使價位不高，食材新鮮度仍維持得很好，能感受到店家對品質的堅持。

綜合評分

地址：403臺中市西區公益路288號

電話：0910855180

官網：https://giafine100.com/

小結語

加分100%浜中特選昆布鍋物是一間「不浮誇、但會讓人想再訪」的火鍋店。它不追求豪華擺盤，而是用最簡單的湯頭與新鮮食材，傳遞出家常卻不平凡的溫度。
如果你想在公益路找一間可以放心帶家人一起吃的鍋物店，這裡絕對會讓人感到「加分」不少。

印月餐廳｜中式料理的藝術演繹，宴客與家庭聚會首選

說到臺中公益路的中式料理代表，印月餐廳 絕對是榜上有名。這間開業多年的餐廳以「中菜西吃」的概念聞名，把傳統中式料理以現代手法重新詮釋。從建築外觀到餐具擺設，每個細節都散發著低調的典雅氣息。
走進印月，挑高的空間、柔和的燈光與木質桌椅構成沉穩的氛圍。
不論是家庭聚餐、商務宴客，還是節日慶祝，都能找到恰到好處的格調。

餐點特色

印月最令人印象深刻的是他們將傳統中菜融入創意手法。
這次我品嚐的「松露雞湯」香氣濃郁、層次分明，一口下去既有中式的溫潤感，又帶出西式松露的奢華香氣。
「蒜香牛肋條」則是另一道招牌菜，外酥內嫩、油香十足，咬下去肉汁在口中散開，搭配特調醬汁非常過癮。
此外，他們的創意港點如「麻辣小籠包」與「金沙流沙包」也深受年輕客群喜愛，既保留經典又玩出新意。

用餐體驗

服務方面完全對得起餐廳的高級定位。從入座、點餐到上菜節奏，都拿捏得恰如其分。每道菜都會有服務人員細心介紹食材與吃法，讓人感受到「被款待」的尊榮感。
雖然價位偏中高，但在這樣的氛圍與品質下，物有所值。

綜合評分

地址：408臺中市南屯區公益路二段818號

電話：0422511155

官網：https://wein818.com/

小結語

印月餐廳是一間「不只吃飯，更像品味生活」的地方。
它成功地讓中式料理不再只是圓桌菜，而是能展現質感、講究細節的美食體驗。
若你在找一間能同時滿足味蕾與體面的餐廳，印月 絕對是公益路上的不敗經典。

KoDō 和牛燒肉｜極致職人精神，專為儀式感與頂級味覺而生

若要形容 KoDō 和牛燒肉 的用餐體驗，一句話足以總結——「像在欣賞一場關於肉的表演」。
隱身在公益路一隅，KoDō 的外觀低調典雅，店內以深色木質調與間接照明營造出沉穩氛圍。
從踏入店門那一刻開始，服務人員的態度、動線、聲音控制，全都精準到位，讓人彷彿走進日式劇場。

餐點特色

這裡主打 日本A5和牛冷藏肉，以「精切厚燒」的方式呈現。
我點的「壽喜燒風和牛套餐」是本日最驚艷的一道——服務人員現場以鐵鍋輕煎，再淋上特製壽喜燒醬汁，香氣瞬間瀰漫整桌。
肉片油花細緻、入口即化，搭配生蛋液後更添柔滑口感。
另一道「冷藏肋眼心」則保留了和牛的彈性與甜度，每一口都能感受到油脂與炭火交織出的層次。
即使是配角如「季節小菜」與「日式和風飯」也毫不馬虎，整體呈現出高級卻不造作的平衡。

用餐體驗

KoDō 的最大特色是「儀式感」。
每位店員的動作都有節奏，從擺盤、火候、換網到講解，都像排練過無數次的演出。
在這裡用餐，會自然地放慢速度，專注於每一口肉帶來的細膩變化。
特別推薦搭配店內的紅酒或日本威士忌，風味更加圓潤。

綜合評分

地址：403臺中市西區公益路260號

電話：0423220312

官網：https://www.facebook.com/kodo2018/

小結語

KoDō 和牛燒肉不是日常餐廳，而是一場體驗。
從環境、服務到食材，每個細節都讓人感受到對「完美」的執著。
若你想在公益路找一間能讓人留下深刻印象、適合紀念日慶祝的餐廳，KoDō 絕對是值得收藏的一次「味覺儀式」。

永心鳳茶｜在茶香裡用餐的優雅時光，臺味早午餐的新詮釋

走進 永心鳳茶公益店，彷彿進入一間有氣質的茶館。
柔和的燈光灑在復古綠牆上，搭配大理石桌面與金色餐具，整體氛圍既典雅又帶有一絲文青氣息。
這裡不只是喝茶的地方，更像是把「臺灣味」以早午餐的形式重新演繹。

餐點特色

永心鳳茶的餐點結合中式靈魂與西式擺盤，無論是「炸雞腿飯」還是「紅玉紅茶拿鐵」，都能讓人感受到熟悉卻不平凡的味道。
炸雞腿外酥內嫩，搭配自製酸菜與溏心蛋，鹹香中帶著層次感。
「鳳茶甜點拼盤」則以茶為靈魂——伯爵茶蛋糕、烏龍茶奶酪、紅茶雪酥，每一口都有細緻的香氣變化。
最特別的是他們的茶飲，從臺灣高山紅茶到金萱冷泡茶，每一壺都現泡現倒，香氣清雅。
對我而言，這不只是一頓飯，更是一段放鬆的午後儀式。

用餐體驗

店內服務人員態度溫和，對茶品介紹詳盡。上餐節奏剛好，不急不徐。
整體氛圍很「耐坐」，許多客人吃完正餐後仍會續點一壺茶聊天。
音樂輕柔、光線柔和，是那種可以靜靜待上兩小時的地方。

綜合評分

地址：40360臺中市西區公益路68號三樓(勤美誠品)

電話：0423221118

官網：https://linktr.ee/yonshin

小結語

永心鳳茶讓人重新定義「臺味」。
它不走傳統路線，而是把熟悉的元素以更細緻、更現代的方式呈現。
無論是姊妹下午茶、親子餐聚，或是想一個人沉澱片刻，永心鳳茶 都是一處能讓人慢下來、品味生活的好地方。

三希樓｜老饕級江浙功夫菜，穩重又帶人情味的中式饗宴

位於公益路上的 三希樓 是許多臺中老饕的口袋名單。
它沒有浮誇的裝潢，卻有一種低調的自信。從大門進入，就能聞到淡淡的醬香與蒸氣味，那是正宗江浙菜的靈魂。
整體裝潢以深木色為主，搭配圓桌與包廂設計，非常適合家庭聚餐或請客宴會。

餐點特色

三希樓的菜色以 江浙與港式料理 為主，兼顧傳統與現代風味。
我這次點了「東坡肉」與「蝦仁炒飯」，兩道都展現了主廚深厚的火候功力。
東坡肉油亮卻不膩，入口即化、鹹甜交織；蝦仁炒飯粒粒分明、香氣十足，每一口都吃得到鑊氣。
此外，「小籠包」皮薄多汁，是幾乎每桌必點的招牌；港點類如「金牌流沙包」與「干貝燒賣」也都表現穩定。

用餐體驗

三希樓的服務給人一種老派但貼心的感覺。
店員上菜節奏掌握得很好，會主動幫忙分菜、收盤，態度沉穩而不打擾。
最讓我印象深刻的是，這裡的客群非常多元——有帶長輩的家庭、公司聚餐，也有情侶共度節日，卻都能在同一空間裡感到自在。

綜合評分

地址：408臺中市南屯區公益路二段95號

電話：0423202322

官網：https://www.sanxilou.com.tw/

小結語

三希樓是一間「吃得出功夫」的餐廳。
它不追求創新，而是用穩定的味道與真材實料，抓住每一位饕客的胃。
如果你想在公益路上找一間能兼顧長輩口味、氣氛又不拘謹的中餐廳，三希樓 絕對是最穩妥的選擇。

一笈壽司｜低調奢華的無菜單日料，職人手藝詮釋旬味極致

在熱鬧的公益路上，一笈壽司 低調得幾乎不顯眼。
外觀簡約，沒有華麗招牌，只有小小的木質門面與柔黃燈光。
一推開門，迎面而來的是日式杉木香氣與寧靜的氛圍，吧檯座位整齊排列，主廚站在中間，彷彿舞臺上的演出者。

餐點特色

一笈壽司採 Omakase（無菜單料理） 形式，每一餐都由主廚根據當日食材設計。
我這次選擇中價位套餐（約 $1200），共十多道料理，從前菜、小鉢、刺身、握壽司到甜點一氣呵成。
「比目魚鰭邊握」是整場最驚豔的瞬間——主廚以火槍輕炙，油脂瞬間釋放，入口後化成柔滑香氣。
「甜蝦海膽軍艦」則完美展現鮮度與層次感，海膽甘甜、甜蝦緊實。
搭配主廚親自調配的醬汁，每一口都像在品嚐季節的節奏。

用餐體驗

整場用餐約90分鐘，節奏緩慢但沉穩。
主廚會邊料理邊與客人互動，介紹魚種產地與食材處理方式。
雖然整體空間不大，但氣氛極佳——柔和的音樂、清酒的香氣、刀刃切魚時的聲音，讓人完全沉浸其中。
特別喜歡他們最後的甜點「焙茶奶酪」，收尾清爽優雅，為整場體驗畫下完美句點。

綜合評分

地址：408臺中市南屯區公益路二段25號

電話：0423206368

官網：https://www.facebook.com/YIJI.sushi/

小結語

一笈壽司是一間真正讓人「放慢呼吸」的餐廳。
這裡沒有多餘擺盤，也不靠噱頭，而是以主廚對食材的尊重與技術堆疊出一場味覺饗宴。
若你想在公益路體驗日本料理最純粹的精神，一笈壽司 絕對值得你預約、靜靜期待。

茶六燒肉堂｜人氣爆棚的和牛燒肉聖地，肉香與幸福感同時滿分

若要票選公益路上「最難訂位」的餐廳，茶六燒肉堂 絕對名列前茅。
不管平日或假日，用餐時段幾乎一位難求。外觀以木質格柵搭配大面玻璃設計，呈現出年輕又有質感的風格。店內空間明亮、桌距適中，播放著輕快的音樂，整體氛圍熱鬧中帶點高級感，是許多年輕人聚餐、慶生的首選地。

餐點特色

茶六主打 和牛燒肉套餐，價格約落在 $700–$1000 間，份量與品質兼具。
我這次點的是「厚切牛舌套餐」，肉片厚實彈牙，略帶脆感，搭配鹽蔥提味剛剛好。
另一道「和牛拼盤」也相當受歡迎，油花分布均勻、香氣濃郁，輕烤幾秒即可入口即化。
套餐附餐部分也相當用心：沙拉新鮮、味噌湯濃郁，最後還有一份「茶香冰淇淋」作結尾，香氣清爽，完美收尾。

用餐體驗

茶六的服務效率相當高。店員親切、換網勤快、補水速度快，整場用餐流程流暢無壓力。
雖然客人很多，但環境維持得乾淨整潔，動線規劃良好。
最令人印象深刻的是他們的 整體節奏拿捏得剛剛好 ——餐點上桌快、氣氛熱絡，卻不會讓人覺得匆忙。
不論是朋友聚會、家庭聚餐，甚至是情侶約會，都能找到各自的樂趣。

綜合評分

地址：403臺中市西區公益路268號

電話：0423281167

官網：https://inline.app/booking/-L93VSXuz8o86ahWDRg0:inline-live-karuizawa/-LUYUEIOYwa7GCUpAFWA

小結語

茶六燒肉堂用「穩定品質＋輕奢氛圍」抓住了臺中年輕族群的心。
不論是第一次約會還是老朋友重聚，都能在這裡找到屬於燒肉的快樂節奏。
若你在公益路只想挑一家「保證不踩雷」的燒肉店，茶六燒肉堂 絕對是首選。

吃完10家公益路餐廳後的心得與結語

吃完這十家餐廳後，臺中公益路不只是一條美食街，而是一段生活風景線。

有的餐廳講究細膩與儀式感，像 一頭牛日式燒肉 與 一笈壽司，讓人感受到食材最純粹的美好

有的則以親切與溫度打動人心，像 加分昆布鍋物、永心鳳茶，讓人明白吃飯不只是為了飽足，而是一種被照顧的幸福。

而像茶六燒肉堂、TANG Zhan 湯棧 這類人氣名店，則用穩定的品質與熱絡的氛圍，成為許多臺中人心中「想吃肉就去那裡」的代名詞。

這十家店，構成了公益路最動人的縮影

有華麗的，也有溫柔的；有傳統的，也有創新的。

 每一家都在自己的風格裡發光，讓人吃到的不只是料理，而是一種生活的溫度與節奏。

對我而言，這不僅是一場美食旅程，更是一趟關於「臺中味道」的回憶之旅。

FAQ：關於臺中公益路美食常見問題

Q1：公益路哪一區的餐廳最集中？
 最熱鬧的區段大約在「公益路與黎明路口」一帶，這裡聚集了許多知名餐廳，從高級燒肉到早午餐通通有。
像 一頭牛日式燒肉、TANG Zhan 湯棧、茶六燒肉堂 都在這附近，交通方便、停車也相對容易。

Q2：需要提前訂位嗎？
 公益路的熱門餐廳幾乎都建議 提早3～5天訂位，尤其是假日或節慶期間。
特別是 一頭牛日式燒肉、KoDō 和牛燒肉、一笈壽司 這幾家，若臨時前往幾乎很難有位。

最後的話

若要用一句話形容這趟美食之旅，我會說：
「在公益路，吃飯不是選擇，而是一種享受。」
這條路上的每一次用餐，都像一段城市裡的小旅行。
下次當你不確定想吃什麼時，不妨沿著公益路走一圈，或許下一家，正好就是你新的最愛。

KoDō 和牛燒肉商務聚餐適合嗎？

如果你也和我一樣喜歡用味蕾探索一座城市，那就把這篇公益路美食攻略收藏起來吧。加分100%浜中特選昆布鍋物適合多人團聚嗎？

無論是約會、慶生、家庭聚餐，或只是想犒賞一下辛苦的自己——這條路上永遠會有一間剛剛好的餐廳在等你。加分100%浜中特選昆布鍋物單點比較好嗎？

下一餐，不妨從這10家開始。NINI 尼尼臺中店婚前派對適合嗎？

打開手機、約上朋友，讓公益路成為你生活裡最容易抵達的小確幸。印月餐廳公司聚餐適合嗎？

如果你有私心愛店，也歡迎留言分享，印月餐廳上餐速度快嗎？

你的推薦，可能讓我下一趟美食旅程變得更精彩。茶六燒肉堂春酒菜色豐富嗎？

The holotype specimen of Lomankus edgecombei. Photograph at left, other images at right are 3D models from CT scanning. Credit: Luke Parry (photograph), Yu Liu, Ruixin Ran (3D models) Researchers have unearthed an eye-catching, gold-colored fossil of a bug in New York, preserved in pyrite for 450 million years. This specimen, Lomankus edgecombei, offers a unique glimpse into the life of ancient arthropods, showcasing its specialized appendages and shedding light on the evolutionary history preserved in Beecher’s Bed, a notable fossil-rich area. Discovery of a Golden Ancient Species Paleontologists have discovered fossils of an ancient bug species that has spent 450 million years preserved in a layer of fool’s gold in central New York. This new species, named Lomankus edgecombei, is a distant ancestor of modern horseshoe crabs, scorpions, and spiders. It had no eyes, and its small front appendages were specialized for digging through dark ocean sediment, dating back to when New York state was submerged underwater. The fossilized remains of Lomankus shine with a bright, golden hue thanks to layers of pyrite, commonly known as fool’s gold, that settled into its structure over time. Life reconstruction of Lomankus edgecombei. Credit: Xiaodong Wang This golden coating isn’t just a visual marvel. The pyrite, found in a fossil-rich site near Rome, New York, called “Beecher’s Bed,” helped preserve Lomankus by gradually replacing its soft tissue as it decayed, preserving intricate details of the ancient creature. “These remarkable fossils show how rapid replacement of delicate anatomical features in pyrite before they decay, which is a signature feature of Beecher’s Bed, preserves critical evidence of the evolution of life in the oceans 450 million years ago,” said Derek Briggs, the G. Evelyn Hutchinson Professor of Earth and Planetary Sciences in Yale’s Faculty of Arts and Sciences. Evolutionary Insights From Lomankus Edgecombei Briggs is co-author of a new study published today (October 29) in Current Biology describing the new species. He is also a curator at the Yale Peabody Museum. Briggs and his co-authors said Lomankus, which is part of an extinct group of arthropods called Megacheira, is evolutionarily significant in several ways. Like other Megacheirans, Lomankus is an example of an arthropod with an adaptable head and specialized appendages (a scorpion’s claws and a spider’s fangs are other examples). In the case of Lomankus, its front appendages bear a trio of long, flexible, whip-like flagella — which may have been used to perceive its surroundings and detect food. The head of Lomankus edgecombei. From left to right: photograph of a specimen preserved so that the head is viewed from the top; 3D model of the same specimen rotated so that the underside is visible; photograph of the head of the holotype specimen; digital 3D model of the head of the holotype specimen. Credit: Luke Parry (photograph), Yu Liu, Ruixin Ran (3D models) “Arthropods typically have one or more pairs of legs at the front of their bodies that are modified for specialized functions like sensing the environment and capturing prey,” said Luke Parry, a former Yale postdoctoral researcher who is now an associate professor at the University of Oxford, and co-corresponding author of the study. “These special legs make them very adaptable, somewhat like a biological Swiss army knife.” In addition, the Lomankus fossils indicate that Megacheirans continued to evolve and diversify longer than previously thought. Lomankus is one of the only known Megacheirans to have survived past the Cambrian Period (485 to 541 million years ago) and into the Ordovician Period (443 to 485 million years ago). Paleontologists believe Megacheirans were largely extinct by the beginning of the Ordovician Period. A Century of Paleontological Research at Yale The new Lomankus fossils also have several ties to Yale’s paleontological efforts, going back more than a century. The site where they were discovered, Beecher’s Bed, is named for Charles Emerson Beecher, who was head of the Yale Peabody Museum from 1899 until 1904. Beecher published classic papers on the anatomy and relationships of trilobites (one of the earliest arthropod groups) from the site, and his material was studied and expanded upon by other scientists for generations. Briggs was one of them. His first paper on Beecher’s Bed fossils was published in 1991, and as curator of invertebrate paleontology at the Peabody in the early 2000s (and subsequently director of the museum), he arranged for Yale to lease the site for field studies until 2009. Paleontologist Yu Liu of Yunnan University in China, co-corresponding author of the study, contacted Briggs about the new fossils from Beecher’s Bed, which he had acquired from a Chinese fossil collector. Briggs then brought in Parry, his former postdoc, with whom he was already collaborating on research about similar fossils at the Peabody. “The preservation is remarkable,” Briggs said. “The density of the pyrite contrasts with that of the mudstone in which they were buried. Their details were extracted based on computed tomography [CT] scanning, which gave us 3D images of the fossils.” The new fossil specimens have been donated to the Peabody. Reference: “A pyritized Ordovician leanchoiliid arthropod” by Luke A. Parry, Derek E.G. Briggs, Ruixin Ran, Robert J. O’Flynn, Huijuan Mai, Elizabeth G. Clark and Yu Liu, 29 October 2024, Current Biology. DOI: 10.1016/j.cub.2024.10.013

A global collaboration has created the world’s most comprehensive primate brain atlas with 4.2 million cells, unveiling region-specific functionalities and associations with neurological diseases, paving the way for future brain research and disease interventions. More than 4 million cells profiled to make largest atlas to date to help explore the evolution of the human brain and new targets for disease and treatments. A longstanding mystery in science is how the over 100 million individual neurons work together to form a network that forms the basis of who we are – every human thought, emotion, and behavior. A Global Brain Mapping Initiative Mapping these constellations of cells and discovering their function have been long-standing goals of scores of 21st century molecular cartographers working worldwide as part of the National Institutes of Health’s “Brain Initiative Cell Census Network” project. The overarching purpose of the atlas is to aid in the development of neuroscience research. The hope of the project is that it will allow scientists to gain a better understanding of brain diseases and hard-to-solve medical mysteries behind disorders such as autism and depression. Groundbreaking Discoveries Now, a series of new studies has revealed the widespread profiles of the inner molecular workings of the brain at an unprecedented level and scale. As part of the effort to better understand the evolution of the brains in people and animals, a research team led by scientists at Arizona State University, University of Pennsylvania, the University of Washington, and the Brotman Baty Institute generated the world’s largest primate brain-wide atlas. “Mapping what cells are where and what they do in the adult primate brain is crucial both for understanding the evolution of human cognition and behavior as well as for identifying what happens when things go wrong and lead to neurological disorders,” said senior co-author Noah Snyder-Mackler, an associate professor at Arizona State University’s School of Life Sciences and Center for Evolution and Medicine. Their goal was to identify and examine many of the brain cells (neurons and non-neurons) and perform a complete molecular analysis using state-of-the-art single-cell technologies. To do so, they used samples from 30 different brain regions to draw out and build up, cell by cell, a new atlas. Altogether, the final map was composed of a 4.2 million cellular atlas of the adult primate brain. “Our data, which we have made open and available to the scientific community and broader public, represent the largest and most comprehensive multimodal molecular atlas in a primate to date, and are crucial for exploring how the many cells of the brain come together to give rise to the behavioral complexity of primates including humans,” said senior co-author Jay Shendure, a professor of Genome Sciences at the University of Washington and Director of the Brotman Baty Institute. “These data will also provide a critical and much-needed map of complex human-relevant social behavior and disease, as well as the substrate for identifying similarities and differences in these cells and networks across species,” said senior co-author Michael Platt, a professor in the Departments of Neuroscience, Psychology, and Marketing at the University of Pennsylvania. Delving Deeper: Multi-Omic Analysis For every cell nucleus, the scientists profiled gene expression (2.58 million transcriptomes) and a suite of complementary DNA gene regulatory regions (1.59 million epigenomes). Taken together, this type of “multi-omic” analysis allowed the authors to study the molecular blueprints that make up distinct brain cell types, thus providing an opportunity to study, and even manipulate, key cells in more detail. From the gene expression profiles, they were able to identify hundreds of molecularly distinct brain cell types. They also found that cell composition differed extensively across the brain, revealing cellular signatures of region-specific functions, from the neurotransmitters involved in brain cell communication to support cells that help feed and protect the brain from diseases like Alzheimer’s. They used their data to investigate a total of 53 phenotypes relevant to risk of neurological diseases, disorders, syndromes, behaviors, or other traits. Their results captured known roles of cell classes implicated in neurological diseases, including cells linked to cardioembolic stroke or ischemic stroke, the leading cause of neurological death in people. They also found that genes linked to Alzheimer’s disease tended to fall within DNA regulatory regions that are only accessible in microglia—the brain’s primary immune cell that protects neurons—consistent with the prominent role of microglia proliferation and activation in Alzheimer’s disease found from genome-wide association studies (GWAS). Many of the regulatory regions they identified were new, which allowed the team to explore the genetic architecture of neurological disease risk at the cellular level. “We identified numerous associations between genetic risk for neurological disorders and the epigenomic states of specific cell types–some of which had yet to be connected,” said co-lead author Kenneth Chiou, postdoc in the Center for Evolution and Medicine and School of Life Sciences at ASU. Another type of cell class, basket cells, were enriched for the greatest number of GWAS phenotypes, including disorders such as schizophrenia, bipolar disorder, major depressive disorder and, most strongly, epilepsy. They also found enrichment of Parkinson’s disease-associated sites among open regions in the glial OPC, oligodendrocyte, and astrocyte cell classes. Finally, they found that heritable sites associated with attention deficit/hyperactivity disorder (ADHD) in their analysis were enriched only among open regions of medium spiny neurons. Medium spiny neurons have been linked to behavioral hyperactivity and disrupted attention via activation of astrocyte-mediated synaptogenesis. Their results suggest that medium spiny neurons may be a promising new target for future ADHD-related study. Together, “multi-omic” atlas now provides an open resource to the worldwide research community for further investigations into the evolution of the human brain and identifying novel targets for disease interventions. Reference: “A single-cell multi-omic atlas spanning the adult rhesus macaque brain” by Kenneth L. Chiou, Xingfan Huang, Martin O. Bohlen, Sébastien Tremblay, Alex R. DeCasien, Diana R. O’Day, Cailyn H. Spurrell, Aishwarya A. Gogate, Trisha M. Zintel, Cayo Biobank Research Unit, Madeline G. Andrews, Melween I. Martínez, Lea M. Starita, Michael J. Montague, Michael L. Platt, Jay Shendure and Noah Snyder-Mackler, 12 October 2023, Science Advances. DOI: 10.1126/sciadv.adh1914

The Key Largo tree cactus was initially found growing in the United States in 1992 at a single site. That population has since been lost to a combination of rising sea levels and increasingly intense storms. Credit: Photo courtesy of Susan Kolterman The United States has witnessed the local extinction of the Key Largo tree cactus due to sea level rise, a first in the country. The cactus, already under pressure from salt water intrusion, hurricanes, and animal grazing, has seen its last remaining stems salvaged for cultivation to prevent total extinction. The United States has witnessed the complete loss of its sole population of the large Key Largo tree cactus, a development that researchers attribute to the first local extinction of a species in the country due to sea level rise. The Key Largo tree cactus (Pilosocereus millspaughii) still grows on a few scattered islands in the Caribbean, including northern Cuba and parts of the Bahamas. In the United States, it was restricted to a single population in the Florida Keys, first discovered in 1992 and monitored intermittently since.  Saltwater intrusion from rising seas, soil depletion from hurricanes and high tides, and herbivory by mammals had put significant pressure on the population. By 2021, what had been a thriving stand of about 150 stems was reduced to six ailing fragments, which researchers salvaged for off-site cultivation to ensure their survival. “Unfortunately, the Key Largo tree cactus may be a bellwether for how other low-lying coastal plants will respond to climate change,” said Jennifer Possley, director of regional conservation at Fairchild Tropical Botanic Garden and lead author on a study published Tuesday, July 9 that documents the population’s decline. Two closely related cacti negatively affected by environmental change Comparatively little is known about Florida’s rare cacti. Researchers initially stumbled upon the Key Largo tree cactus in an isolated mangrove forest, and for several years afterward, its identity remained uncertain. Most considered it to be a unique population of the similarly named Key tree cactus (Pilosocereus robinii), a federally endangered species that is present elsewhere in the Florida Keys. The two cacti have a similar appearance. The stems of both shoot up perpendicular to the ground and can grow to be more than 20 feet tall. Both have cream-colored flowers that smell like garlic and reflect moonlight, attracting bat pollinators, while their bright red and purple fruit catch the eye of birds and mammals. The Key Largo tree cactus can grow to impressive heights. Credit: Photo courtesy of Susan Kolterman But there are key differences as well, which made Alan Franck, currently the herbarium collection manager at the Florida Museum of Natural History, suspect they were dealing with something unique on Key Largo. “The most striking difference is the tuft of long, woolly hairs at the base of the flowers and fruits,” Franck said. The hair is so thick, it can look as though the cactus is covered in drifts of snow. Spines of the Key Largo cactus are also twice as long as they are on the Key tree cactus. In 2019, Franck confirmed that the Key Largo population was the first and only known instance of Pilosocereus millspaughii in the U.S. By then, it was succumbing to some of the same environmental pressures that had plagued its relative, the Key tree cactus, over the last century. The latter was once common throughout the Florida Keys, but its numbers dipped dangerously low as more people moved to the area. Writing in 1917, botanist John Small noted that the Key tree cactus “was for a long time very abundant [on Key West]…In recent years, with the destruction of the hammock for securing firewood and for developing building sites, this interesting cactus has become scarce, until at present it is on the verge of extermination in its natural habitat.” The Key tree cactus was listed as federally endangered in 1984, but its numbers continued to wane. Between 1994 and 2007, it decreased by 84%. Researchers at Fairchild began monitoring all of the tree cactus populations annually in 2007, working in tandem with local land managers. One Fairchild-led study showed that salt levels were higher in soil beneath dead vs. living cacti in the years following a storm surge event in the Lower Keys, drawing a clear connection between mortality and increased salinity. Researchers also initiated a robust conservation collection for these species. Potted cacti are grown at a facility in Coral Gables, Florida, and seeds from both wild and cultivated plants are carefully banked for long-term conservation. Researchers study and rescue the remnants of a dwindling stock The Key Largo tree cactus grew on a low limestone outcrop surrounded by mangroves near the shore. The site originally had a distinct layer of soil and organic matter that allowed the cactus and other plants to grow, but storm surge from hurricanes and exceptionally high tides eroded away this material until there wasn’t much left. Salt-tolerant plants that had been previously restricted to brackish soils beneath the mangroves slowly began creeping up the outcrop, an indication that salt levels were increasing. Given enough time, these changing conditions would likely have killed the cactus. But other incidents occurred that hastened the pace. Staff from Fairchild and the Florida Department of Environmental Protection removed all remaining green material in 2021 after it became clear the population was not going to survive. Credit: Photo courtesy of Jennifer Possley “We noticed the first big problem in 2015,” said study co-author James Lange, a research botanist at Fairchild. When he and his colleagues arrived to evaluate the plants that year, half of the cacti had died, apparently as a result of an alarming amount of herbivory. Cacti store reserves of water in their succulent stems, which allows them to survive for long periods of time without rain. This makes them enticing to animals when other sources of water are scarce. “In 2011, we started seeing saltwater flooding from king tides in the area,” Lange said, referring to particularly high ocean tides. “That limits the amount of freshwater available to small mammals and might be related to why the herbivores targeted this cactus, but we can’t say for sure. We’d never seen cactus herbivory like this anywhere in the Lower Keys, where flooding has tended to be less extensive.” The team set out cameras in hopes of finding the culprit, but whatever it was did not return, and there was no evidence of significant herbivory thereafter. Yet, when the team came back the following year, roughly another 50% of the population had died. In response, staff from Fairchild and the Florida Department of Environmental Protection took a few cuttings of what remained to grow in greenhouses. In 2017, category 5 Hurricane Irma swept across South Florida, creating a 5-foot storm surge. The highest point on Key Largo is only 15 feet above sea level, and large portions of the island remained flooded for days afterward. Once the storm had passed, the Fairchild team conducted triage with several cactus populations throughout the Keys, removing branches that had fallen on cacti and salvaging other ill-fated material. Conditions were so extreme that biologists had to put out kiddie pools of freshwater to keep local wildlife alive. Exacerbating the already degrading Key Largo tree cactus habitat, king tides in 2019 left large portions of the island, including the extremely low-lying outcrop, flooded for over three months. By 2021, there were only six Key Largo tree cactus stems left. As it was clear the population wasn’t going to survive, the team allowed the plants to flower and fruit for the remainder of the year, then salvaged all remaining green material and replanted it in greenhouses or controlled settings outdoors. At present, researchers know of no naturally growing Key Largo cacti in the United States. “We have tentative plans with the Florida Department of Environmental Protection to replant some in the wild,” Possley said.  Similar efforts are responsible, in large part, for the continued existence of the related Key tree cactus in Florida. “The amount of reintroduced material of this species is already more than the amount of wild material that’s left,” Possley said. But, she added, this may end up being more of a stopgap than a solution. Environments suitable for tree cacti are disappearing along with the plants they support. “It’s generally a fringe between the mangroves and upland hammocks called thorn scrub, and there just aren’t many places like that left where we can put reintroduced populations.” The decline of the Key Largo tree cactus and the necessity of its removal has given researchers an idea of what to expect in the future as species contend with a rapidly warming world. Instead of a smooth, predictable rise in sea or salt levels, the reality of climate change is messier and manifests itself in a complex series of related events that put additional pressure on species that are already stressed. “We are on the front lines of biodiversity loss,” said study co-author George Gann, executive director for the Institute for Regional Conservation. “Our research in South Florida over the past 25 years shows that more than one in four native plant species are critically threatened with regional extinction or are already extirpated due to habitat loss, over-collecting, invasive species, and other drivers of degradation. More than 50 are already gone, including four global extinctions.” Reference: “First U.S. vascular plant extirpation linked to sea level rise? Pilosocereus millspaughii (Cactaceae) in the Florida Keys, U.S.A.” by Jennifer Possley, James J. Lange, Alan R. Franck, George D. Gann, Trudy Wilson, Susan Kolterman, Janice Duquesnel and Joseph O’Brien, 9 July 2024, Journal of the Botanical Research Institute of Texas. DOI: 10.17348/jbrit.v18.i1.1350 The study was funded by the Florida Department of Agriculture and Consumer Services.

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